NBI 35965 hydrochloride

Overview

NBI 35965 hydrochloride is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a K i value of 4 nM and a pK i value of 8.5. NBI 35965 hydrochloride does not inhibit CRF2. NBI 35965 hydrochloride reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC 50 values of 7.1 and 6.9, respectively. NBI 35965 hydrochloride shows anxiolytic effects.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > CRFR

Product Information

• Catalog No.: HY-110056
• CAS No.: 1782228-59-4
• Molecular Formula: C21H23Cl3N4
• Molecular Weight: 437.79
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source