N-Acetyl-L-leucyl-L-leucyl-L-methional

Overview

N-Acetyl-L-leucyl-L-leucyl-L-methional is a Calpain II inhibitor with an IC 50 of 0.24 μM against porcine Calpain II. N-Acetyl-L-leucyl-L-leucyl-L-methional forms a stable tetrahedral adduct with the thiol group at the active site of Calpain II, thereby inhibiting proteolytic activity. N-Acetyl-L-leucyl-L-leucyl-L-methionally inhibits cathepsins in a non-selective manner. N-Acetyl-L-leucyl-L-leucyl-L-methional reduces SARS-CoV-2 infection levels in human coronary artery endothelial cells in vitro. N-Acetyl-L-leucyl-L-leucyl-L-methional can be used in research related to cataracts and coronavirus infections.

Application

Products | Products > Disease Areas > Visual System Disease | Products > Disease Areas > Coronavirus Infection | Products > Disease Areas > Cataract | Products > Disease Areas > Infection | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cytoskeleton | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Neurological Disease | Products > Research Areas > Infection | Products > Signaling Pathways > Proteasome | Products > Signaling Pathways > Calpain | Products > Signaling Pathways > SARS-CoV

Product Information

• Catalog No.: HY-103321
• CAS No.: 145757-50-2
• Molecular Formula: C18H33N3O4S
• Molecular Weight: 387.54
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source