J-113863 (Standard)

Overview

J-113863 (Standard) is the analytical standard of J-113863 ( HY-103360 ). This product is intended for research and analytical applications. J-113863 is a potent and selective CCR1 antagonist with IC 50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. J-113863 is also a potent antagonist of the human CCR3 (IC 50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC 50 of 460 nM). J-113863 is inactive against CCR2 , CCR4 and CCR5 , as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect.

Application

Products | Products > Signaling Pathways > Others | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Reference Standards | Products > Signaling Pathways > CCR

Product Information

• Catalog No.: HY-103360R
• CAS No.: 353791-85-2
• Molecular Formula: C30H37Cl2IN2O2
• Molecular Weight: 655.44
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source