Eeyarestatin I

Overview

Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects.

Application

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Product Information

• Catalog No.: HY-110078
• CAS No.: 412960-54-4
• Molecular Formula: C27H25Cl2N7O7
• Molecular Weight: 630.44
• Purity: 99.56%
• Storage: -20°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: 1.25 mg/mL (1.98 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source