Elsulfavirine (Standard)

Overview

Elsulfavirine (Standard) is the analytical standard of Elsulfavirine ( HY-109056 ). This product is intended for research and analytical applications. Elsulfavirine (R-1206) is an orally active human carbonic anhydrase ( carbonic anhydrase , CA ) inhibitor and an allosteric inhibitor of HIV-1 non-nucleoside reverse transcriptase (NNRT). Elsulfavirine also targets and blocks the interaction between adenylosuccinate lyase (ADSL) and insulin-induced gene proteins INSIG1/2, blocks SREBP-1-mediated de novo lipid synthesis, and inhibits the proliferation of liver cancer cells. The combination of Elsulfavirine and Lenvatinib ( HY-10981 ) produces a synergistic anti-tumor effect. Elsulfavirine is converted into the active metabolite VM1500A in vivo, blocks the DNA polymerase activity of reverse transcriptase , and inhibits HIV-1 replication. Elsulfavirine exhibits a K i of 1960 nM-52400 nM against human carbonic anhydrase isoforms including I, VII, VI, VA, VB, IX, XIII, XIV. Elsulfavirine is used in studies related to HIV-1 infection and liver cancer .

Application

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Product Information

• Catalog No.: HY-109056R
• CAS No.: 868046-19-9
• Molecular Formula: C24H17BrCl2FN3O5S
• Molecular Weight: 629.28
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source