Furamidine

Overview

Furamidine (DB75) is a selective protein arginine methyltransferase 1 ( PRMT1 ) inhibitor with an IC 50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5 , PRMT6 , and PRMT4 (CARM1) (IC 50 s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also an antiparasite agent.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Histone Methyltransferase | Products > Signaling Pathways > Phosphodiesterase (PDE) | Products > Signaling Pathways > Parasite

Product Information

• Catalog No.: HY-110137A
• CAS No.: 73819-26-8
• Molecular Formula: C18H16N4O
• Molecular Weight: 304.35
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source