BTT-369

Overview

BTT-369 is a Ca V α 1 ·Ca V β 3 protein-protein complex antagonist with a K i of 2.0 μM. BTT-369 inhibits Ca V 2.2 currents, with an apparent IC 50 value of 31 μM. BTT-369 disrupts the interaction between Ca V α 1 and Ca V β 3 subunits. BTT-369 reduces the current density of Ca V 2.2 , and shifts the voltage dependence of steady-state inactivation and activation of Ca V 2.2 to more positive potentials. BTT-369 alleviates mechanical hyperalgesia in a rat model of tibial nerve injury. BTT-369 can be used for the study of neuropathic pain.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Pain | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Calcium Channel

Product Information

• Catalog No.: HY-115596
• CAS No.: 2413939-96-3
• Molecular Formula: C34H28N8O2
• Molecular Weight: 580.64
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source