PU-11

Overview

PU-11 is a Hsp90α / Hsp90β inhibitor with IC 50 values of 18.6 μM and 89.8 μM and K d values of 2 and 4.2 μM. PU-11 binds to the ATP-binding pocket of Hsp90α and Hsp90β and displays selective binding preference for Hsp90α over Hsp90β , mediated by the nonconserved Hsp90α Ser52 residue. PU-11 can be used for the research of neurodegenerative disorders.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > HSP

Product Information

• Catalog No.: HY-116053
• CAS No.: 1454619-18-1
• Molecular Formula: C19H23N5O3
• Molecular Weight: 369.43
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source