EVP-0015962

Overview

EVP-0015962 is an orally active, blood-brain barrier-permeable γ-secretase inhibitor with an IC 50 of 3.9 μM. EVP-0015962 alters γ-secretase-mediated cleavage of amyloid precursor protein, reduces Aβ 42 production and increases Aβ 38 production. EVP-0015962 reduces Aβ aggregates, amyloid plaques and inflammatory markers in the brains of mice, and improves their cognitive impairment. EVP-0015962 can be used for the research of Alzheimer's disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > γ-secretase | Products > Signaling Pathways > Amyloid-β

Product Information

• Catalog No.: HY-117521
• CAS No.: 1447811-26-8
• Molecular Formula: C22H19ClF6O3
• Molecular Weight: 480.83
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source