GYKI 53784

Overview

GYKI 53784 (LY303070) is an orally active, blood-brain penetrant, selective, non-competitive AMPA receptor antagonist ( IC 50 = 0.32 μM). GYKI 53784 completely blocks AMPA -mediated synaptic transmission, protects against excitotoxicity, and partially inhibits Kainite (Kainic acid) ( HY-N2309 ) responses, revealing both AMPA and kainate receptors. GYKI 53784 selectively blocks synaptic transmission ( IC 50 = 365.3 nM) without affecting neuronal excitability, and exhibits potent stereoselective antinociceptive effects via an opioid-independent mechanism. GYKI 53784 is a versatile tool for studying AMPA receptor function in synaptic transmission, excitotoxicity, neuroprotection, pain, and inflammation, with potential relevance to hearing loss, neonatal ischemia, neurodegenerative disorders, schizophrenia, and Alzheimer's disease.

Application

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Product Information

• Catalog No.: HY-118278
• CAS No.: 161832-71-9
• Molecular Formula: C19H20N4O3
• Molecular Weight: 352.39
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source