Dehydrosertindole is a blood-brain barrier-permeable, orally active inhibitor of the dopamine D 2 receptor . Dehydrosertindole occupies striatal dopamine D 2 receptors to mediate receptor regulation. Dehydrosertindole is the active metabolite of Sertindole ( HY-14543 ), which distributes rapidly in guinea pig myocardium and inhibits conditioned avoidance responses in rats. Dehydrosertindole can be used in research related to schizophrenia.
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