ARI-809

Overview

ARI-809 (CP-744809) is a highly selective, orally active aldose reductase inhibitor with an IC 50 of 1 nM. ARI-809 blocks excessive glucose flux through the polyol pathway. ARI-809 normalizes elevated sorbitol and fructose levels in sciatic nerve tissues of diabetic rat models, inhibits sorbitol accumulation in lens tissues, and brings elevated urinary albumin excretion close to normal. ARI-809 can be used in diabetes research.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Glucose Metabolism | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Aldose Reductase

Product Information

• Catalog No.: HY-119058
• CAS No.: 463976-07-0
• Molecular Formula: C13H9ClN2O4S
• Molecular Weight: 324.74
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source