BC12

Overview

BC12 is a barbituric acid derivative and a phosphodiesterase 7 ( PDE7 ) inhibitor, with an IC 50 of 0.77 μM against human targets. BC12 inhibits the enzymatic activity of PDE7 , but this activity is not the driver of its immunomodulatory effects on T lymphocytes. BC12 blocks the upregulation of IL-2 transcription in activated T cells. BC12 modulates the transcriptional response of T cells upon stimulation, exerting anti-inflammatory and pro-stress effects. BC12 inhibits the proliferation of primary mouse T cells and the IL-2 secretion of human peripheral blood T lymphocytes. BC12 exerts immunosuppressive and immunomodulatory effects on T lymphocyte function. BC12 can be used in research related to T lymphocyte-mediated diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Phosphodiesterase (PDE) | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-119514
• CAS No.: 423744-89-2
• Molecular Formula: C21H19N3O3
• Molecular Weight: 361.39
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source