GAT100

Overview

GAT100 is a negative allosteric modulator and covalent allosteric probe for cannabinoid receptor type 1 ( CB1R ). GAT100 acts as a positive allosteric modulator for orthosteric agonist CP55,940 binding to regulate the CB1R signaling pathway. GAT100 reduces the potency and efficacy of orthosteric CB1R agonists in terms of β-arrestin 1 recruitment, phosphorylation of PLCβ3 and ERK1/2 , cAMP accumulation, and CB1R internalization. GAT100 is applicable to the research of psychobehavioral and somatic diseases.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Cannabinoid Receptor | Products > Signaling Pathways > PERK

Product Information

• Catalog No.: HY-120093
• CAS No.: 1663564-42-8
• Molecular Formula: C25H28N4OS
• Molecular Weight: 432.59
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source