4-CPI

Overview

4-CPI (4-(4-Chlorophenyl)imidazole) is a CYP2B4 inhibitor with an IC 50 of 0.11 μM and a K d of 0.043 μM. The K s of 4-CPI for cytochrome P450eryF (S93C/C154S mutant) is 9.4 μM, with no allosteric cooperative effect of ligand binding. 4-CPI binds to CYP2B4 at a 1:1 ratio, which induces substantial conformational changes in the enzyme's active pocket to form a closed crystal conformation (PDB:1SUO). 4-CPI can be used to investigate the flexibility of P450 active pockets, protein-ligand binding thermodynamics, and the allosteric mechanisms of P450.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Others | Products > Signaling Pathways > Cytochrome P450

Product Information

• Catalog No.: HY-121946
• CAS No.: 35512-29-9
• Molecular Formula: C9H7ClN2
• Molecular Weight: 178.62
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Source

Original product source