CSLP43

Overview

CSLP43 is a selective RIPK2 and XIAP inhibitor with an IC 50 of 19.9 nM against human RIPK2 . CSLP43 binds to the ATP-binding pocket of RIPK2 and disrupts the interaction between RIPK2 and the BIR2 domain of XIAP or cIAP1 . CSLP43 inhibits RIPK2 ubiquitination, NOD1 -dependent inflammatory signaling pathways, NOD2 -dependent inflammatory signaling pathways, as well as NF-κB activation associated with NOD agonists. CSLP43 is selective for the NOD1 / NOD2 signaling pathway and does not inhibit the kinase activity of RIPK1 or RIPK3 . CSLP43 is applicable to research related to Crohn's disease, Blau syndrome, early-onset sarcoidosis and early-onset inflammatory bowel disease.

Application

Products | Products > Disease Areas > Pathogens Infection | Products > Disease Areas > Digestive System Inflammation | Products > Disease Areas > Crohn's Disease | Products > Disease Areas > Gastroenteritis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Autoimmune Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > IAP | Products > Signaling Pathways > NOD-like Receptor (NLR)

Product Information

• Catalog No.: HY-123925
• CAS No.: 2244988-80-3
• Molecular Formula: C26H33N5O4S
• Molecular Weight: 511.64
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source