RO5126946

Overview

RO5126946 is a selective, orally active α7 nAChR allosteric potentiator with EC 50 values of 0.06 μM ( hα7 nAChR ) and 770 nM ( α7 nAChR ), and it crosses the blood-brain barrier. RO5126946 enhances synaptic transmission and positively modulates GABA -ergic responses by increasing peak current, slowing current decay, and elevating the frequency of spontaneous inhibitory postsynaptic currents, without affecting the recovery of receptors from the desensitized state. RO5126946 not only enhances subthreshold nicotine effects and improves associative learning, but also does not interfere with the original pro-cognitive effects of nicotine. RO5126946 can be used to study cognitive impairments associated with diseases such as Alzheimer's disease and schizophrenia.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Schizophrenia | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > nAChR

Product Information

• Catalog No.: HY-124057
• CAS No.: 1137233-79-4
• Molecular Formula: C19H21ClN2O4S
• Molecular Weight: 408.90
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source