LR1143

Overview

LR1143 is a dopamine transporter ( DAT ) and 5-HT uptake inhibitor, with IC 50 values of 3.4 nM and 112 nM in rats, respectively. LR1143 binds to DAT labeled with the dopamine reuptake inhibitor GBR 12935 ( HY-12242A ), with an IC 50 of 4.4 nM. LR1143 shows lower selectivity for DAT than for serotonin reuptake sites. LR1143 can be used in studies related to cocaine abuse.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Behavioral Addiction | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Dopamine Receptor | Products > Signaling Pathways > 5-HT Receptor

Product Information

• Catalog No.: HY-124186
• CAS No.: 150151-15-8
• Molecular Formula: C29H34F2N2O
• Molecular Weight: 464.59
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source