CPU-228

Overview

CPU-228 is a complex class III antiarrhythmic agent. CPU-228 concentration-dependently blocks the activities of the rapid component 50 of the delayed rectifier potassium channel ( I Kr ) and the L-type calcium channel ( I Ca ,L ), with an IC 50 value of 0.909 μM for I Ca ,L current. CPU-228 produces negative inotropic effects and induces mild, non-frequency-dependent prolongation of the effective refractory period (ERP) in isolated left atria. CPU-228 reduces the incidence of torsades de pointes (TDP) in anesthetized rabbits and inhibits ischemia/reperfusion-induced arrhythmias in rats. CPU-228 can be used in studies related to torsades de pointes.

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Heart Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Calcium Channel | Products > Signaling Pathways > Potassium Channel

Product Information

• Catalog No.: HY-124940
• CAS No.: 446877-42-5
• Molecular Formula: C23H26N2O4S
• Molecular Weight: 426.53
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source