RTI-371

Overview

RTI-371 is a highly selective atypical dopamine transporter (DAT) inhibitor that crosses the blood-brain barrier. RTI-371 exhibits potent inhibitory activity in cell lines transfected with human DAT ( IC 50 = 8.7 nM) and shows high binding affinity for rat DAT with a K i value of 7.81 nM. RTI-371 also acts as a positive allosteric modulator of the human cannabinoid 1 receptor (hCB1 receptor), enhancing the activity of cannabinoid receptor agonists in a concentration-dependent manner. RTI-371 can be used for the research of Parkinson's disease.

Application

Products | Products > Disease Areas > Parkinson's Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Dopamine Transporter | Products > Signaling Pathways > Serotonin Transporter | Products > Signaling Pathways > Cannabinoid Receptor | Products > Signaling Pathways > Sigma Receptor

Product Information

• Catalog No.: HY-129215
• CAS No.: 652978-45-5
• Molecular Formula: C24H25ClN2O
• Molecular Weight: 392.92
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source