NMDAR blocker 1

Overview

NMDAR blocker 1 is an NMDA receptor channel blocker with an IC 50 of 5.0 μM. NMDAR blocker 1 exhibits fast on-off blockade kinetics and strong voltage dependence, and does not compete with glutamate or glycine. NMDAR blocker 1 prevents glutamate/NMDA-induced intracellular Ca 2+ overload, modulates the glutamate-nitric oxide-cGMP pathway. NMDAR blocker 1 prevents in vitro excitotoxic neurodegeneration of cultured cerebellar and hippocampal neurons. NMDAR blocker 1 attenuates excitotoxic insult in an mouse model of hyperammonemia-induced excitotoxicity. NMDAR blocker 1 can be used for the research of neurodegenerative diseases.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > iGluR | Products > Signaling Pathways > Calcium Channel

Product Information

• Catalog No.: HY-131691
• CAS No.: 76991-05-4
• Molecular Formula: C17H20N2O
• Molecular Weight: 268.36
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source