SN-38- 13 C 6

Overview

SN-38 - 13 C 6 (7-Ethyl-10-hydroxycamptothecin- 13 C 6 ) is the 13 C-labeled SN-38 ( HY-13704 ). SN-38 is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 can bind to RPL15. SN-38 inhibits DNA and RNA synthesis with IC 50 s of 0.077 and 1.3 μM, respectively. SN-38 is a payload of sacituzumab govitecan (HY -132254).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Infection | Products > Signaling Pathways > Others | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Antibody-Drug Conjugate/ADC Related | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Infection | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Drug Metabolite | Products > Signaling Pathways > Isotope-Labeled Compounds | Products > Signaling Pathways > Topoisomerase | Products > Signaling Pathways > ADC Payloads

Product Information

• Catalog No.: HY-13704S2
• CAS No.: 718612-55-6
• Molecular Formula: C1613C6H20N2O5
• Molecular Weight: 398.36
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source