PF-05221304 tromethamine

Overview

PF-05221304 tromethamine is an orally active, liver-directed and dual ACC1/ACC2 inhibitor with IC 50 s of 7.5 nM for rat ACC1, 8.2 nM for rat ACC2. PF-05221304 tromethamine is a substrate for organic anion transport polypeptides . PF-05221304 tromethamine directly improves a variety of non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) pathogenic factors.

Application

Products | Products > Disease Areas > Liver Disease | Products > Disease Areas > Fatty Liver Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Lipid Metabolism | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Acetyl-CoA Carboxylase | Products > Signaling Pathways > OAT

Product Information

• Catalog No.: HY-137846A
• CAS No.: 2334472-62-5
• Molecular Formula: C32H41N5O8
• Molecular Weight: 623.71
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source