E-6837 is a selective and orally active 5-HT 6 receptor ligand. E-6837 demonstrates partial agonism at a presumably silent rat 5-HT 6 receptor and full agonism at a constitutively active human 5-HT 6 receptor by monitoring the cAMP signaling pathway. E-6837 induces hypophagia, reduces fat mass and body weight, and improves glycemic control. E-6837 can be used for the research of obesity.
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