KJM429

Overview

KJM429 (MK-056) is a high-affinity ligand for the rat vanilloid receptor rTRPV1 ( K i =30-63 nM) with a unique dual regulatory function. KJM429 acts as a competitive antagonist to inhibit TRPV1 receptor activation induced by Capsaicin ( HY-10448 ), resiniferatoxin, thermal stimulation and weak acid (pH 6.0), and switches to a TRPV1 agonist under strong acid conditions (pH<5.5). KJM429 effectively blocks calcium influx induced by Capsaicin and partial thermal stimulation, and triggers calcium uptake under low pH conditions, with minimal effects on non-TRPV1-mediated calcium signaling. KJM429 can be used for research on the mechanisms of pain-related diseases such as postherpetic neuralgia, diabetic neuropathy, cluster headache, osteoarthritis and pruritus.

Application

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Product Information

• Catalog No.: HY-165459
• CAS No.: 401907-57-1
• Molecular Formula: C20H27N3O2S2
• Molecular Weight: 405.58
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source