PUMAi

Overview

PUMAi is a PUMA inhibitor that disrupts the interaction between PUMA and BCL-xL . PUMAi inhibits apoptosis , caspase-3 activation, WNT/NOTCH pathway activation, and DNA damage. PUMAi protects intestinal tissues in mice, promotes the growth of colonoids, and reduces chemotherapy-induced weight loss, gastrointestinal damage, and lethality. PUMAi alleviates acetaminophen-induced liver injury and cytoplasmic translocation of HMGB1 in mice. PUMAi can be used in studies related to gastrointestinal injury, intestinal injury, and liver injury.

Application

Products | Products > Disease Areas > Gastric Disease | Products > Disease Areas > Liver Disease | Products > Disease Areas > Digestive System Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Notch | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-167182
• CAS No.: 470695-03-5
• Molecular Formula: C19H28Cl2N2O3
• Molecular Weight: 403.34
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source