PROTAC LRRK2 Degrader-2 is a PROTAC-based degrader targeting LRRK2 with a DC 50 of 0.14 nM. PROTAC LRRK2 Degrader-2 recruits LRRK2 or its mutants to the cereblon E3 ubiquitin ligase , thereby mediating the targeted ubiquitination and subsequent proteasomal degradation of LRRK2 . PROTAC LRRK2 Degrader-2 can be used in research related to Parkinson's disease.
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