DOT1L705

Overview

DOT1L705 is a PROTAC degrader that targets DOT1L . DOT1L705 recruits the VHL E3 ubiquitin ligase to induce proteasomal degradation of DOT1L . DOT1L705 reduces the viability of leukemia cells. DOT1L705 inhibits H3K79 methylation. DOT1L705 can be used in studies related to MLL-rearranged leukemia. (Pink: DOT1L ligand ( HY-135127 ); Blue: VHL ligand ( HY-150802 ); Black: linker).

Application

Products | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Blood Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Histone Methyltransferase

Product Information

• Catalog No.: HY-181787
• CAS No.: 3050756-34-5
• Molecular Formula: C61H72ClF3N12O13S2
• Molecular Weight: 1337.88
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source