TLR7 antagonist-1

Overview

TLR7 antagonist-1 (Compound 44#) is an orally active, selective TLR7 antagonist with an IC 50 value of 0.3 nM against TLR7 . TLR7 antagonist-1 selectively binds to TLR7 , inhibits its activation, and downregulates the c-Rel signaling pathway. TLR7 antagonist-1 downregulates the mRNA levels of proinflammatory cytokines IL-1β , IL-6 , and TNF-α . TLR7 antagonist-1 alleviates Imiquimod ( HY-B0180 )-induced psoriasis-like skin lesions. TLR7 antagonist-1 is applicable to research related to psoriasis.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Skin Inflammation | Products > Disease Areas > Psoriasis | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-181796
• CAS No.: 3104353-70-7
• Molecular Formula: C21H25ClF3N5O
• Molecular Weight: 455.90
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source