PROTAC BET Degrader-16

Overview

PROTAC BET Degrader-16 (Compound A10) is a BET PROTAC degrader with a DC 50 of 0.31 nM against BRD4 , and it preferentially targets BRD4 over other BET family members. PROTAC BET Degrader-16 degrades BRD2 , BRD3 and BRD4 via the ubiquitin-proteasome system, a process that requires target binding and recruitment of the CRBN E3 ligase . PROTAC BET Degrader-16 induces cell cycle arrest and promotes apoptosis . PROTAC BET Degrader-16 exerts anti-tumor activity against acute myeloid leukemia. (Pink: BET Target protein ligand; Blue: Cereblon ligand ( HY-A0003 ); Black: linker ( HY-W018678 )).

Application

Products | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Blood Disease | Products > Disease Areas > Acute Myeloid Leukemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-181867
• CAS No.: 2410947-65-6
• Molecular Formula: C44H45F2N7O9S
• Molecular Weight: 885.93
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source