JAK1-IN-20

Overview

JAK1-IN-20 (Compound 38) is a gut-restricted, orally active, selective JAK1 inhibitor with an IC 50 of <0.5 nM. JAK1-IN-20 inhibits the enzymatic activity of JAK1 , reduces the production of proinflammatory cytokines ( TNF-α , IL-6 ), and suppresses the phosphorylation of STAT3 . JAK1-IN-20 ameliorates ulcerative colitis. JAK1-IN-20 can be used for the research of inflammatory bowel disease.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Peptic Ulcer Disease | Products > Disease Areas > Ulcerative Colitis | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > JAK | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-181872
• CAS No.: 3106963-85-0
• Molecular Formula: C26H25ClFN7O3
• Molecular Weight: 537.97
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source