Autotaxin-IN-8

Overview

Autotaxin-IN-8 (Compound 14E) is an orally active Autotaxin inhibitor with an IC 50 of 14.2 nM against hAutotaxin. Autotaxin-IN-8 inhibits Autotaxin activity, MAPK activation, LPAR1 and p-ERK1/2 . Autotaxin-IN-8 reduces the phosphorylation levels of JNK and p38 . Autotaxin-IN-8 decreases collagen deposition in a mouse model of pulmonary fibrosis. Autotaxin-IN-8 can be used in research related to pulmonary fibrosis.

Application

Products | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Lung Fibrosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > JNK | Products > Signaling Pathways > Phosphodiesterase (PDE) | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > LPL Receptor | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-181931
• CAS No.: 3058084-21-9
• Molecular Formula: C21H20ClN9O
• Molecular Weight: 449.90
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source