STIM1-TFR1-IN-1

Overview

STIM1-TFR1-IN-1 is an orally active stromal interaction molecule 1 ( STIM1 ) -transferrin receptor 1 ( TFR1 ) protein complex inhibitor with a K d of 2.18 μM for STIM1-CD protein. STIM1-TFR1-IN-1 blocks STIM1-TFR1 interaction and reduce TFR1-mediated iron uptake activity. STIM1-TFR1-IN-1 inhibits ferroptosis , lipid peroxidation and ROS production, enhances glutathione peroxidase 4 ( GPX4 ) activity and glutathione/oxidized glutathione ratio, and rescues ferroptosis-associated mitochondrial morphological changes. STIM1-TFR1-IN-1 exhibits neuroprotective effects and reduces brain injury. STIM1-TFR1-IN-1 can be used for the research of intracerebral hemorrhage.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Transferrin Receptor | Products > Signaling Pathways > Ferroptosis | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > Glutathione Peroxidase

Product Information

• Catalog No.: HY-181953
• CAS No.: 2196106-61-1
• Molecular Formula: C15H21N5OS
• Molecular Weight: 319.43
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source