NEURL1B-IN-1

Overview

NEURL1B-IN-1 is a molecular glue-like NEURL1B degrader with a Kd value of 46.2 nM. NEURL1B-IN-1 binds to Arg422 within the NHR2 domain of NEURL1B , triggers its autoubiquitination and proteasomal degradation, disrupts its interaction with DLL1 , and attenuates the Notch signaling pathway. NEURL1B-IN-1 induces cell cycle arrest and apoptosis , and inhibits migration of hepatocellular carcinoma cells. NEURL1B-IN-1 is applicable to research related to hepatocellular carcinoma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > E1/E2/E3 Enzyme | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Notch | Products > Signaling Pathways > PARP | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > Ligands for E3 Ligase | Products > Signaling Pathways > Molecular Glues

Product Information

• Catalog No.: HY-182008
• CAS No.: 3068938-30-4
• Molecular Formula: C30H38O5
• Molecular Weight: 478.62
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source