PROTAC ATR degrader-3

Overview

PROTAC ATR degrader-3 is a potent CRBN-based ATR PROTAC degrader with a DC 50 of 127 nM. PROTAC ATR degrader-3 also degrades CHK1 with an DC 50 of 135 nM. PROTAC ATR degrader-3 inhibits cancer cells proliferation, migration and invasion, triggers apoptosis and induces S phase arrest and DNA damage. PROTAC ATR degrader-3 achieves tumor growth inhibition in LoVo xenograft mouse model without apparent toxicity. PROTAC ATR degrader-3 can be used for the research of colorectal cancer . (Pink: ATR ligand ( HY-182017 ); Blue: Cereblon ligand ( HY-W077589A ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA/RNA Synthesis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > Bcl-2 Family | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > ATM/ATR | Products > Signaling Pathways > Checkpoint Kinase (Chk) | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-182016
• CAS No.: 3126270-11-6
• Molecular Formula: C41H38N8O6
• Molecular Weight: 738.79
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source