NNMT-IN-8

Overview

NNMT-IN-8 is a non- SAM -mimicking bisubstrate inhibitor and a selective methyltransferase NNMT inhibitor, with IC 50 values of 0.0084 μM and 0.0085 μM against human NNMT , and an IC 50 of 0.0072 μM against mouse NNMT . NNMT-IN-8 exhibits prominent renal distribution characteristics and moderate bioavailability in rodents. NNMT-IN-8 dose-dependently inhibits renal NNMT in renal fibrosis models, thereby exerting antifibrotic effects. NNMT-IN-8 can be used to investigate the mechanisms of renal fibrosis.

Application

Products | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Renal Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Amine N-methyltransferase

Product Information

• Catalog No.: HY-182021
• CAS No.: 3124204-81-2
• Molecular Formula: C23H25FN4O2S
• Molecular Weight: 440.53
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source