HD202A

Overview

HD202A is an orally active, selective dual inhibitor of MNK1/MNK2 (with IC 50 values of 6.09 nM and 8.06 nM, and K d values of 1.913 μM and 5.244 μM, respectively) that inhibits the MNK-eIF4E signaling pathway. By downregulating perilipin 2 and SCD1 , while upregulating adipose triglyceride lipase and PPARγ coactivator 1α, HD202A enhances mitochondrial fatty acid oxidation and redox homeostasis. HD202A effectively suppresses body weight gain, hepatic lipid accumulation and elevation of serum lipids, significantly improves glucose tolerance and insulin sensitivity of the organism, and ameliorates inflammatory features. With these comprehensive pharmacological activities, HD202A exhibits great application potential in studies of metabolic dysfunction-associated steatotic liver disease.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Lipid Metabolism | Products > Disease Areas > Fatty Liver Disease | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > MNK | Products > Signaling Pathways > PPAR | Products > Signaling Pathways > Eukaryotic Initiation Factor (eIF) | Products > Signaling Pathways > Stearoyl-CoA Desaturase (SCD)

Product Information

• Catalog No.: HY-182046
• CAS No.: 2930131-74-9
• Molecular Formula: C25H24N6OS
• Molecular Weight: 456.56
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source