DM243

Overview

DM243 is an EPAC1 activator and STAT3 modulator with an pIC 50 of 4.769 for EPAC1. DM243 increases GTP-bound Rap1 levels in EPAC1 -expressing cells. DM243 reduces IL-6 / IL-6Rα -evoked STAT3 phosphorylation in endothelial cells. DM243 suppresses TGF-β1 -induced fibroblast-to-myofibroblast transition, reducing α-smooth muscle actin and Collagen I levels in lung fibroblasts. DM243 exhibits minimal cytotoxicity in normal human lung fibroblasts.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Others | Products > Signaling Pathways > STAT | Products > Signaling Pathways > Acyltransferase

Product Information

• Catalog No.: HY-182273
• CAS No.: 3106606-59-8
• Molecular Formula: C22H21NO6
• Molecular Weight: 395.41
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source