DM245

Overview

DM245 is an EPAC1 activator and STAT3 phosphorylation inhibitor with a target pIC 50 of 4.801. DM245 activates EPAC1 to increase Rap1-GTP levels, with no activation of EPAC2 or PKA . DM245 reduces IL-6/IL-6Rα-evoked STAT3 phosphorylation in endothelial cells. DM245 suppresses TGF-β1-induced fibroblast-to-myofibroblast transition, reducing αSMA and Collagen I levels. DM245 exhibits minimal cytotoxicity in normal human lung fibroblasts, with negligible loss of intact nuclei after 72 h exposure.

Application

Products | Products > Disease Areas > Others | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Others | Products > Signaling Pathways > Acyltransferase | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-182274
• CAS No.: 3106606-60-1
• Molecular Formula: C25H21NO5
• Molecular Weight: 415.44
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source