SGK1-IN-7 is a blood-brain barrier-permeable SGK1 inhibitor with an IC 50 of 0.72 μM. SGK1-IN-7 reduces the phosphorylation level of TAU protein at the Ser396 and Ser214 epitopes. SGK1-IN-7 antagonizes the toxicity induced by Okadaic acid ( HY-N6785 ). SGK1-IN-7 can be used in the research of Alzheimer's disease.
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