DM-1157

Overview

DM-1157 is an orally active asymmetric bisquinoline heme inhibitor with a IC 50 of 1.6 μM and a K d of 1.7 μM. DM-1157 binds to heme dimers in solution, inhibits β-hematin formation, suppresses hemozoin formation in the digestive vacuole of Plasmodium falciparum , accumulates in the digestive vacuole of Plasmodium falciparum , induces enlargement of the digestive vacuole of Plasmodium falciparum , and inhibits the growth of Chloroquine ( HY-17589A )-sensitive and resistant Plasmodium falciparum strains. DM-1157 can be used for the research of malaria and Plasmodium falciparum -type malaria.

Application

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Product Information

• Catalog No.: HY-182394
• CAS No.: 1239953-66-2
• Molecular Formula: C28H31ClN6
• Molecular Weight: 487.04
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source