SMases D-IN-1

Overview

SMases D-IN-1 is an inhibitor of SMase D (sphingomyelinase D) from Loxosceles (brown recluse spider), with a K i value of 0.54 μM. SMases D-IN-1 inhibits the hydrolysis of sphingomyelin substrates by recombinant and native SMases D, reduces the binding ability of SMases D to human red blood cells, and prevents the shedding of glycophorin C from the surface of human red blood cells. SMases D-IN-1 partially inhibits Loxosceles venom-induced death of human keratinocytes and also suppresses systemic reactions triggered by Loxosceles venom. SMases D-IN-1 can be used in studies related to recluse spider envenomation.

Application

Products | Products > Disease Areas > Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Infection | Products > Signaling Pathways > Phospholipase

Product Information

• Catalog No.: HY-182413
• CAS No.: 849020-48-0
• Molecular Formula: C19H16N4O3S2
• Molecular Weight: 412.49
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source