RO5328673

Overview

RO5328673 is an orally active, blood-brain barrier permeable neurokinin receptor antagonist that effectively targets human NK3 receptors ( K i =0.4 nM, K a =0.1 nM), human NK2 receptors ( K i =1.1 nM, K a =0.9 nM), and guinea pig NK3 receptors ( K a =0.1 nM and 0.13 nM). RO5328673 acts as an insurmountable antagonist of NK3 receptors with a slow dissociation rate, while it shows rapid association and dissociation rates at human NK2 receptors. RO5328673 potently inhibits senktide ( HY-P0187 )-induced enhancement of spontaneous activity in dopaminergic neurons and reverses senktide-induced changes in motor activity of gerbils. RO5328673 is widely applicable to research related to schizophrenia.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Schizophrenia | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Neurokinin Receptor

Product Information

• Catalog No.: HY-182423
• CAS No.: 1310817-94-7
• Molecular Formula: C29H32Cl2FN3O4
• Molecular Weight: 576.49
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source