NB-533

Overview

NB-533 is an orally active and brain-penetrant BACE-1 inhibitor with a human IC 50 of 0.002 μM. NB-533 also inhibits human cathepsin D with an IC 50 of 0.001 μM. NB-533 inhibits amyloidogenic amyloid precursor protein (APP) processing and reduces Aβ 40 release. NB-533 reduces brain levels of APP metabolite C99 and Aβ 40 in transgenic mice. NB-533 can be used for the research of Alzheimer’s disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Beta-secretase | Products > Signaling Pathways > Cathepsin | Products > Signaling Pathways > Amyloid-β

Product Information

• Catalog No.: HY-182429
• CAS No.: 1146544-18-4
• Molecular Formula: C33H55N3O4
• Molecular Weight: 557.81
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source