FPL 66564 is a short-acting angiotensin-converting enzyme ( ACE ) inhibitor with an IC 50 of 5.7 nM against rabbit ACE . FPL 66564 inhibits ACE activity at the functional level and is hydrolyzed in human blood into inactive hydrophilic metabolites. FPL 66564 modulates angiotensin I-induced pressor responses in anesthetized rats, and its effects rapidly return to baseline after cessation of intravenous infusion. FPL 66564 can be used for research on cardiovascular regulation related to critical illness.
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