RM1490 (Compound 251) acts as an inhibitor of μ-opioid receptor ( MOR ) ( IC 50 ≤ 300 nM), an activator of δ-opioid receptor ( DOR ) ( EC 50 > 3000 nM), and an inhibitor of κ-opioid receptor ( KOR ) ( IC 50 ≤ 300 nM). RM1490 is applicable to the research of neuropsychiatric disorders.
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