AK-42

Overview

AK-42 is a selective CLC-2 chloride channel inhibitor with human IC 50 of 17 nM and rat IC 50 of 14 nM. AK-42 binds to an extracellular vestibule above the channel pore, inhibits CLC-2 currents acutely and reversibly, including with auxiliary subunit GlialCAM coexpression. AK-42 acts as a selective tool compound for acute CLC-2 function modulation to probe CLC-2 neurophysiology. AK-42 can be used for the research of leukodystrophy and idiopathic generalized epilepsies.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Chloride Channel

Product Information

• Catalog No.: HY-182571
• CAS No.: 15437-29-3
• Molecular Formula: C20H15Cl2NO3
• Molecular Weight: 388.24
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source