CFT-743

Overview

CFT-743, a PROTAC -based heterobifunctional degrader and BET inhibtor, is a degrader of BRD4 bromodomain 1 ( BD1 ) with a DC 50 of 4.3 nM. CFT-743's antitumor activitiy is dependent on BET degradation and can be attenuated by Pomalidomide ( HY-10984 ), which is a CRBN binding molecule. CFT-743 induces ubiquitination of BRD4 BD1. CFT-743 can be used for cancer research.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-182577
• CAS No.: 2154350-81-7
• Molecular Formula: C46H49ClN10O3
• Molecular Weight: 825.40
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source