EF-7412

Overview

EF-7412 is a dual antagonist of the 5-HT 1 A receptor and dopamine D 2 receptor, with K i values of 27 nM and 22 nM, respectively. EF-7412 acts as an antagonist at both pre- and postsynaptic 5-HT 1 A receptor sites, blocking 8-OH-DPAT ( HY-112061 )-induced hypothermia, behavioral syndrome, and corticosterone elevation in vivo. EF-7412 increases hypothalamic 5-HIAA/5-HT and DOPAC/DA ratios, alters 5-HT and DA neuronal activity, and slightly decreases spontaneous motor activity. EF-7412 can be used for research on 5-HT 1 A/D 2 receptor regulation and related neural pathways.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > 5-HT Receptor | Products > Signaling Pathways > Dopamine Receptor

Product Information

• Catalog No.: HY-182677
• CAS No.: 221452-76-2
• Molecular Formula: C22H33N5O4S
• Molecular Weight: 463.59
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source