MMV693183

Overview

MMV693183 is an orally active inhibitor of Plasmodium falciparum acetyl-CoA synthetase ( AcAS ), with an IC 50 of 300 nM against Plasmodium falciparum . MMV693183 exhibits potent inhibitory activity against clinical isolates of malaria parasites, including Artemisinin ( HY-B0094 )-resistant strains. MMV693183 is metabolized in vivo into the active antimetabolite CoA-MMV693183, which exerts effects of killing asexual blood-stage parasites and blocking transmission to Anopheles mosquitoes by binding to and inhibiting the function of acetyl-CoA synthetase , thereby reducing the levels of acetyl-CoA and 4'-phosphopantetheine. In humanized mouse models, MMV693183 shows favorable in vivo efficacy, drug-like properties, and no significant cytotoxicity or off-target activity against human cells. MMV693183 is widely used in malaria-related research as a parasiticide and metabolic disruptor.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Parasitic Infection | Products > Disease Areas > Plasmodium Infection | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Acetyl-CoA synthetase | Products > Signaling Pathways > Parasite

Product Information

• Catalog No.: HY-182685
• CAS No.: 2446681-27-0
• Molecular Formula: C16H21F3N2O4
• Molecular Weight: 362.34
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source